Clinical Library

Headache disorder clinical reference.

Evidence-based explainers on headache disorder treatments, drug classes, and mechanisms. Free, no account required.

Condition

Chronic Migraine

Chronic migraine is defined by the ICHD-3 as headache occurring on 15 or more days per month for …

Read article
Drug Class

OnabotulinumtoxinA (Botox) for Chronic Migraine

OnabotulinumtoxinA (Botox) is FDA-approved for chronic migraine prevention (≥15 headache days/mon…

Read article
Drug Class

CGRP Monoclonal Antibodies

First-in-class preventive therapies designed specifically for migraine. Available as Aimovig (ere…

Read article
Drug Class

Gepants (CGRP Receptor Antagonists)

A newer class of migraine treatments that block the CGRP receptor. Available as Nurtec ODT (rimeg…

Read article
Drug Class

Triptans

The most widely used class of prescription acute migraine treatments. Seven triptans are availabl…

Read article
Reference

Medication Overuse Headache

A common but underdiagnosed complication of frequent acute medication use. MOH affects an estimat…

Read article
Epidemiology

Migraine Burden and Prevalence

Migraine affects an estimated 39-40 million people in the United States and approximately 1 billi…

Read article
Epidemiology

Episodic to Chronic Migraine Progression

Approximately 2.5% of people with episodic migraine progress to chronic migraine each year. Risk …

Read article
Policy

Headache Specialist Shortage

There are approximately 900 UCNS-certified headache medicine specialists in the United States — p…

Read article
Policy

Adequate Treatment Rate in Migraine

Studies consistently show that a large majority of people with migraine are not receiving adequat…

Read article
Policy

Payer Policy Barriers in Migraine

Prior authorization requirements, step therapy mandates, and formulary restrictions create substa…

Read article

More topics coming soon — including episodic migraine, CGRP mechanism, and preventive therapy.

Looking for PA guidance? The PA Engine covers 1,205 payers across all 50 states — free for every clinician, no account required.

Run a PA — free